Remplir™ is engineered with Orthocell’s proprietary SMRT™ technology to help patients reclaim touch, movement,  and their lives.1,2

Peripheral nerve repair: A smarter way to support nerve healing

The best predictor of success in peripheral nerve surgery is a tension-free, well-aligned coaptation using minimal epineurial microsutures to optimise axonal regeneration.3 

Yet depending on the type and location of the repair, achieving this can be challenging and outcome predictability has changed little over the past decades.3-5 

Biomaterial choice may play a larger role than previously thought. 

Many materials fail to fully integrate with native tissue, leaving residues that impede healing. Rigid materials can also be difficult to handle and complicate management of size mismatches.6,7 

Remplir is engineered with Orthocell’s proprietary SMRT™ technology to: 

Mimic the natural epineurium with an absolute collagen wrap1
Create an optimal healing environment for nerve regeneration1,2
Be easy to handle and suture-sparing, simplifying the surgical process1,2
Protect the repair site from scarring, adhesions, and inflammation.1

Connect

Enables tensionless repair of transected nerve injuries, supporting direct repairs with or without grafts, as well as nerve transfers and free functioning muscle transfers.1,2 

Protect

Helps manage non-transected nerve injuries by reducing the risk of adhesion formation and supporting smooth nerve gliding in conditions such as carpal and cubital tunnel syndrome.1 

Cap

Prevents neuroma regrowth after resection of a terminal neuroma, or formation of new neuromas post amputation.1 

How It Works

Tensionless repair is highly desirable in nerve reconstruction for several reasons, but primarily because it reduces the risk of additional damage to the nerve. Nerve repair with Remplir™ enables a reduction in suture requirements thus reducing the time needed to complete the surgery. The handling characteristics of Remplir™ assist surgeons perform complex reconstructive surgical procedures with tensionless repair.

Applications

Orthocell develops, manufactures and exports novel regenerative medicine products around the world. Its biological medical devices and cellular therapies are used by leading surgeons to treat musculoskeletal injuries of nerve, tendon and cartilage, and dental bone defects. The clinical results, compelling.

A Versatile Single Solution Device 

Remplir is a highly versatile product that delivers a single solution for surgical repair of peripheral nerve injuries. Remplir provides compression-free protection to the nerve, generating an ideal microenvironment to aid nerve healing.

  • Use straight out of the box – no need to soak or rinse.
  • One product covers all surgical requirements – no need to accurately measure nerve diameter before selecting product.

Protect Every Repair with Remplir™

Remplir is a highly versatile product that delivers a single solution for surgical repair of peripheral nerve injuries. Remplir provides compression-free protection to the nerve, generating an ideal microenvironment to aid nerve healing.

  • Use straight out of the box – no need to soak or rinse.
  • One product covers all surgical requirements – no need to accurately measure nerve diameter before selecting product.
Indications for Use

Remplir is indicated for the management of peripheral nerve injuries in which there has been no substantial loss of nerve tissue.

Contraindications

The use of Remplir in patients with known sensitivity to porcine-derived materials or collagen is contraindicated.

A complete range of nerve wraps

15x20mm

Nerve diameter: Up to 3mm
Order code: OCG-152

20x30mm

Nerve diameter: Up to 5mm
Order code: OCG-203

30x40mm

Nerve diameter: Up to 10mm
Order code: OCG-304

40x50mm

Used for longitudinal wrapping
Order code: OCG-405

For information on how to order Striate+, please contact Orthocell or your local BioHorizons representative

Clinical Evidence

O’Beirne A, paper →

References. 1. Data on file. 2. O’Beirne, A., J. Cullen, E. Landao-Bassonga, M. Zheng, C. Lee, P. Kaluskar, A. Tai and M. Zheng (2024). “Reconstruction of Upper Extremity Peripheral Nerve Injuries Using an Epineurial-Like Collagen Device—A Prospective Clinical Study.” Journal of Reconstructive Microsurgery Open 09(01): e78-e88. 3. Siemionow, M. and G. Brzezicki (2009). “Chapter 8: Current techniques and concepts in peripheral nerve repair.” Int Rev Neurobiol 87: 141-172. 4. Ruijs, A.C., J.B. Jaquet, S. Kalmijn, H. Giele, S.E. Hovius (2005). “Median and ulnar nerve injuries: a meta-analysis of predictors of motor and sensory recovery after modern microsurgical nerve repair.” Plast Reconstr Surg 116(2):484- 94 5. Braga Silva, J., G. M. Marchese, C. G. Cauduro and M. Debiasi (2017). “Nerve conduits for treating peripheral nerve injuries: A systematic literature review.” Hand Surg Rehabil 36(2): 71-85. 6. Aman M, Preisner F, Mayrhofer-Schmid M, et al. Inferior Long-Term Results of a Randomized Controlled Trial Initially Demonstrating Enhanced Sensory Nerve Recovery Using a Chitosan Nerve Tube. Plast Reconstr Surg. 2025;155(2):364- 373. Doi:10.1097/PRS.0000000000011526 7. Zeng W, Osterman M, Stern PJ. Inflammatory Reactions to Xenogenic Nerve Wraps: A Report of Three Cases. JBJS Case Connect. 2019;9(3):e0302. Doi:10.2106/JBJS.CC.18.00302 8. Data on file, 4 weeks post-transection.