Remplir™ is a collagen nerve wrap designed to support the repair and protection of peripheral nerves.
Remplir is a biocompatible, resorbable, collagen nerve wrap intended for the management of peripheral nerve injuries.
Engineered with Orthocell’s proprietary SMRT™ manufacturing technology, Remplir helps patients reclaim touch movement, and their lives.
Remplir™ is a resorbable collagen membrane that provides an ideal microenvironment to aid nerve healing
Collagen technology for nerve repair
Remplir is a purified collagen membrane, designed to mimic the epineurium (the natural outer layer of a nerve). Its structure helps provide a biological protective layer whilst allowing fluids and nutrients to move through the repair environment.
Smooth outer surface
A cell occlusive membrane that reduces the risk of tissue adhesions and facilitates the free gliding of the repaired nerve.
This provides predictable outcomes in restoring functions at an earlier timepoint.
Textured inner surface
Sits against the nerve to provide protective healing microenvironment that supports consistent axon regeneration.
Designed with similar physical characteristics to mimic the epineurium, Remplir fully resorbs as healing progresses.
One wrap for multiple peripheral nerve surgery applications
Remplir may be used across a range of peripheral nerve surgery procedures where the goal is to connect, protect, or cap a nerve.
Connect
Enables tensionless repair of transected nerves, supporting direct repairs (with/without allograft/autograft) as well as nerve transfers and free functioning muscle transfer
Protect
Helps manage non-transected nerve injuries by reducing risk of adhesion formation and supporting nerve gliding in conditions such as carpel and cubital tunnel syndrome.
Cap
Prevents neuroma regrowth after resection of a terminal neuroma, or formation of new neuromas post amputation.
Supporting the nerve healing environment
After injury or peripheral nerve surgery, scarring, inflammation, compression, and tethering can interfere with recovery. Remplir is designed to provide a protective collagen layer around the nerve, helping create a favorable healing environment. Preclinical studies showed Remplir-wrapped nerves with restored nerve structure, minimal adhesion formation, no observed foreign body reaction, and integration with nerve tissue.
Designed for surgical flexibility
Remplir is available in multiple sizes to support different nerve diameters and surgical applications in peripheral nerve surgery.
Part of Orthocell’s regenerative medicine platform
Orthocell develops regenerative medicine solutions that support the repair of soft tissue, bone, tendon, and nerve. Remplir reflects Orthocell’s focus on translating collagen medical device science into practical surgical solutions for peripheral nerve repair.