Orthocell’s autologous tendon therapy is the most advanced injectable cellular therapy for the treatment of chronic tendon injuries.
he patient’s own healthy tendon-derived cells are used to help regenerate damaged tendons, reducing pain and restoring function. The innovative therapy addresses a significant unmet clinical need for a safe, effective, and non-surgical solution. OrthoATI™ is not available for sale, distribution, or clinical use in the United States.
How It Works
Autologous tendon therapy is a two-stage procedure. A biopsy of healthy tendon, typically from the patella tendon, is performed in a doctor’s room using local anaesthetic. The biopsied tissue is sent to Orthocell’s quality-controlled laboratory, where the cellular building blocks of the tendon, the tenocytes, are isolated and grown to a clinically significant number under controlled conditions. Finally, the tendon cells are implanted into the affected tendon approximately 4–5 weeks after the initial biopsy, via an ultrasound-guided injection under local anaesthetic.
Publications
- Bucher TA et al. Autologous tenocyte injection for the treatment of chronic recalcitrant gluteal tendinopathy – A prospective pilot study. Orthop j Sports Med.
2017 Feb - Bhabra G et al. Lateral elbow tendinopathy: development of a pathophysiology-based treatment algorithm. Orthop J Sports Med.
2016 Nov - Raina D et al. A biphasic bone substitute with gentamycin regenerates bone in osteomyelitis with muscle acting as an osteoinductive niche. Orthopaedic Proceedings.
2015 Oct - Wang A et al. Evidence for the durability of autologous tenocyte injection for treatment of chronic resistant lateral epicondylitis – Mean 4.5 year clinical follow-up. AM J Sports Med
2015 Jul - Wang A et al. Autologous tenocyte injection for the treatment of severe, chronic resistant lateral epicondylitis: a pilot study. Am J Sports Med.
2013 Dec - Wang A elt al. Autologous tenocyte implantation, a novel treatment for partial-thickness rotator cuff tear and tendinopathy in an elite athlete. BMJ Case Rep.
2013 Jan - Chen J et al. Autologous Tenocyte therapy for experimental achilles tendinopathy in a rabbit model. Tissue Eng Part A.
2011 Aug - Chen J et al. In chronic lateral epicondylitis, apoptosis and autophagic cell death occur in the extensor carpi radialis brevis tendon. J Shoulder Elbow Surg.
2010 Apr - Chen J et al. Autologous tenocyte therapy using porcine derived bio-scaffolds for massive rotator cuff defects in rabbits. Tissue Eng.
2007 Jul