Remplir™ is a collagen nerve wrap designed to support the repair and protection of peripheral nerves.
Remplir is a biocompatible, resorbable collagen nerve wrap intended for the management of peripheral nerve injuries.
Engineered using Orthocell’s proprietary SMRT™ manufacturing technology, Remplir helps patients reclaim touch, movement and quality of life
Remplir provides an elastic, biocompatible scaffold that helps create a healing microenvironment around repaired or compressed nerves.
Collagen technology for nerve repair
Remplir is made from purified collagen and is designed to mimic the epineurium, the natural outer layer of a nerve. Its structure helps provide a biological protective barrier while allowing fluids and nutrients to move through the repair environment.
Smooth outer surface
The smooth outer surface acts as a cell-occlusive barrier, helping to reduce the risk of tissue adhesions and facilitate free gliding of the repaired nerve.
This supports predictable outcomes and the restoration of function at an earlier time point.
Textured inner surface
The textured inner surface sits against the nerve to provide a protective healing microenvironment that supports consistent axon regeneration.
Designed with similar physical characteristics to the epineurium, Remplir fully resorbs as healing progresses.
One wrap for multiple peripheral nerve surgery applications
Remplir may be used across a range of peripheral nerve surgery procedures where the goal is to connect, protect or cap a nerve.
Connect
Enables tensionless repair of transected nerves, supporting direct repairs, with or without grafts, as well as nerve transfers and free functioning muscle transfers.
Protect
Helps manage non-transected nerve injuries by reducing the risk of adhesion formation and supporting nerve gliding in conditions such as carpal and cubital tunnel syndrome.
Cap
Helps prevent neuroma regrowth after resection of a terminal neuroma or the formation of new neuromas following amputation.
Supporting the nerve healing environment
After injury or peripheral nerve surgery, scarring, inflammation, compression, and tethering can interfere with recovery. Remplir is designed to provide a protective collagen barrier around the nerve, helping create a favourable healing environment. Preclinical studies showed Remplir-wrapped nerves with restored nerve structure, minimal adhesion formation, no observed foreign body reaction, and integration with nerve tissue.
Designed for surgical flexibility
Remplir is available in multiple sizes to support different nerve diameters and surgical applications in peripheral nerve surgery.
Part of Orthocell’s regenerative medicine platform
Orthocell develops regenerative medicine solutions that support the repair of soft tissue, bone, tendon, and nerve. Remplir reflects Orthocell’s focus on translating collagen medical device science into practical surgical solutions for peripheral nerve repair.