Remplir™ is engineered with Orthocell’s proprietary SMRT™ technology to help patients reclaim touch, movement, and their lives.

Peripheral nerve repair: A smarter way to support nerve healing

The best predictor of success in peripheral nerve surgery is a tension-free, well-aligned coaptation using minimal epineurial microsutures to optimise axonal regeneration.

Yet depending on the type and location of the repair, achieving this can be challenging and outcome predictability has changed little over the past decades.

Biomaterial choice may play a larger role than previously thought.

Many materials fail to fully integrate with native tissue, leaving residues that impede healing. Rigid materials can also be difficult to handle and complicate management of size mismatches.

Remplir™ is the ideal biomaterial for nerve repair

Exceptional handling characteristics

By preserving the natural collagen structure, Remplir retains the inherent strength, flexibility, and biocompatibility of type I collagen.

Designed to mimic epineurium, it easily conforms to nerve tissue, accommodates size mismatches between nerve ends, and is easy to suture.

Native collagen architecture

Manufactured from the highest quality porcine peritoneum and processed using the SMRT manufacturing method, the native collagen architecture is preserved without compromising strength or flexibility.

The resulting collagen structure closely resembles human collagen, making Remplir an ideal biomaterial for supporting the regeneration of healthy nerve tissue.

Biocompatible and Non-Immunogenic

Consists of purified type I collagen which is very similar between species, resulting in low immunogenicity and excellent biocompatibility.

SMRT™ manufacturing process thoroughly removes cellular impurities resulting in a pure collagen device without alpha-gal, DNA, and other non-collagenous materials that increase the risk of foreign body reaction after implantation.1

During the healing process, Remplir is completely resorbed and integrated into nerve tissue, with no evidence of foreign body reaction.

Healing microenvironment

The porous natural collagen structure of Remplir allows nutrient flow from surrounding blood vessels.

The smooth outer surface is cell-occlusive, promoting nerve gliding through surrounding soft tissues and minimizing the risk of adhesions while the looser collagen arrangement on the inner surface facilitates cellular attachment and proliferation

How It Works

Tensionless repair is highly desirable in nerve reconstruction for several reasons, but primarily because it reduces the risk of additional damage to the nerve. Nerve repair with Remplir™ enables a reduction in suture requirements thus reducing the time needed to complete the surgery. The handling characteristics of Remplir™ assist surgeons perform complex reconstructive surgical procedures with tensionless repair.

Applications

Orthocell develops, manufactures and exports novel regenerative medicine products around the world. Its biological medical devices and cellular therapies are used by leading surgeons to treat musculoskeletal injuries of nerve, tendon and cartilage, and dental bone defects. The clinical results, compelling.

A Versatile Single Solution Device

Remplir is a highly versatile product that delivers a single solution for surgical repair of peripheral nerve injuries. Remplir provides compression-free protection to the nerve, generating an ideal microenvironment to aid nerve healing.

Use straight out of the box – no need to soak or rinse.
One product covers all surgical requirements – no need to accurately measure nerve diameter before selecting product.

Protect Every Repair with Remplir™

Use straight out of the box – no need to soak or rinse.
One product covers all surgical requirements – no need to accurately measure nerve diameter before selecting product.

Connect

Enables tensionless repair of transected nerve injuries, supporting direct repairs with or without grafts, as well as nerve transfers and free functioning muscle transfers.1,2

Protect

Helps manage non-transected nerve injuries by reducing the risk of adhesion formation and supporting smooth nerve gliding in conditions such as carpal and cubital tunnel syndrome.1